Poisonous Concoction Pathfinder Build Guide (3.18 Sentinel)

TbXie

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Introduction

Poisonous Concoction Poisonous Concoction is a poison-based attack skill introduced in Path of Exile’s 3.16 Scourge League. It offers incredibly clear and an old overlapping style of scaling its damage to the point where it becomes an absolute powerhouse. For players who like to blast through the game on a budget and want a build that is minmaxable with an acceptable amount of currency and incredible returns, this is a one of a kind build.

Mechanics

This build relies on Pathfinder and the insane innate damage of Poisonous Concoction Poisonous Concoction to be able to scale defenses out of this world. In the endgame version it stacks Armour, Evasion, Suppression, Life, Ghost Dance and Elemental Damage reduction to achieve a very durable build. Whilst doing so, it maintains millions of Bossing DPS and way above acceptable clear speed.

The way the build works is by using Life Flask charges to scale up your damage. This is because of the flat added chaos damage you’re getting from the Poisonous Concoction gem. Other than that, there’s a couple of debuff mechanics such as curses (Despair Despair), damage increments (Wither Wither) and additional clear speed Plague Bearer Plague Bearer which round out the build to have it all.

The path of building offers you a starter set of gems & gear and a more optimized lategame selection of items.

Build Viability in Numbers

This is where I’ll rate the build in numbers. The lower the number the worse I actually think the build is in that compartment.

  • Durability : 9/10
  • Damage : 8/10
  • Playstyle : 9/10
  • Gearing : 9/10
  • Complexity : 7/10

Path of Building & Skill Tree

You can find an optimized Path of Building here. Every build I release will use the community fork of Path of Building, which is maintained and updated in a much more regular fashion than the original one. You can find PoB’s Fork, by LocalIdentity, here.

If you are not comfortable with Path of Building, we also have a PoePlanner for you. Do note that PoE Planner does not support Cluster Jewels and some specific unique jewels and it is highly recommended you install Path of Building to follow builds most optimally.

Gem Links

Endgame

Main Link: Poisonous Concoction Poisonous ConcoctionGreater Volley Support Greater Volley SupportAwakened Greater Multiple Projectiles Support Awakened Greater Multiple Projectiles SupportAwakened Unbound Ailments Support Awakened Unbound Ailments SupportAwakened Void Manipulation Support Awakened Void Manipulation SupportAwakened Vicious Projectiles Support Awakened Vicious Projectiles Support

Auras: Vaal Grace Vaal GraceMalevolence MalevolenceHerald of Agony Herald of AgonyDefiance Banner Defiance BannerDetermination DeterminationEnlighten Support Enlighten Support

Make sure to link them all to an enlighten level 3 (by splitting them up in different items).

Utility 1: Withering Step Withering Step Vaal Molten Shell Vaal Molten Shell Cast when Damage Taken Support Cast when Damage Taken Support Ancestral Protector Ancestral Protector

Utliity 2: Plague Bearer Plague BearerIncreased Area of Effect Support Increased Area of Effect SupportEnhance Support Enhance SupportBlood Rage Blood Rage

League Start

Main Link: Poisonous Concoction Poisonous ConcoctionGreater Volley Support Greater Volley SupportGreater Multiple Projectiles Support Greater Multiple Projectiles Support Unbound Ailments Support Unbound Ailments SupportVoid Manipulation Support Void Manipulation SupportVicious Projectiles Support Vicious Projectiles Support

Auras: Vaal Grace Vaal GraceMalevolence MalevolenceHerald of Agony Herald of AgonyDefiance Banner Defiance Banner

Utility 1: Withering Step Withering StepVaal Molten Shell Vaal Molten ShellCast when Damage Taken Support Cast when Damage Taken Support#

Utility 2: Plague Bearer Plague BearerIncreased Area of Effect Support Increased Area of Effect SupportBlood Rage Blood RageDespair Despair

Utility 3: Wither WitherAncestral Protector Ancestral ProtectorMultiple Totems Support Multiple Totems SupportFaster Casting Support Faster Casting Support

Gear Summary

Early Game – Leaguestart Environment:

Item Slot Item Name
Head Rare Evasion Helmet with Life, Resistance, Spell Suppression & a Poisonous Concoction AoE enchant
Amulet Agate Amulet Agate Amulet with Life & some Damage over Time Multiplier
Chest Rare Chestpiece with Life, Spell Suppression & Maximum Life as Energy Shield craft
Gloves Rare Evasion/Energy Shield with Life, chance to Suppress Spell Damage, Resistances (Potentially Attack Speed)
Boots Rare Evasion Boots with Life, Movement Speed, chance to Suppress Spell Damage & Resistances or Atziri's Step Atziri's Step
Belt Rare Belt with Strength, Life, Resistances
Rings Rare Rings with Life, Resistances & Attributes
Shield Lycosidae Lycosidae

Lategames:

Item Slot Item Name
Head Rare Evasion Helmet with Life, Resistance, Nearby Enemies take 9% increased Chaos Damage & a Poisonous Concoction AoE enchant
Amulet Catalysed Agate Amulet Agate Amulet with Life, Malevolence Reservation Efficiency, -8 Mana Cost, Area of Effect
Chest Rare Chestpiece with Life, Spell Suppression & Maximum Life as Energy Shield craft
Gloves Rare Evasion/Energy Shield with Life, Attack Speed, Chaos DoT Multi, Resistances
Boots Atziri's Step Atziri's Step
Belt Rare Belt with Strength, Life, % increased Life, Flask Effect, Resistances
Rings Catalysed Iolite Ring Iolite Rings with Life, Resistances, -8 Mana Cost, Despair on hit & Attributes
Shield Lycosidae Lycosidae
Jewels Increased Maximum Life, Chaos Damage over Time Multiplier, Damage with Poison

Flasks

1 Granite Flask Granite Flask of the Armadillo
2 Sulphur Flask Sulphur Flask of the Owl
3 Silver Flask Silver Flask of Dove
4 Saturated Eternal Life Flask Eternal Life Flask
5 Quicksilver Flask Quicksilver Flask of the Cheetah

The Cheetah affix should be swapped to a Catarina Benchcraft for Reduced Mana Costs once you swap to the late game aura setup to reduce the cost of your Poisonous Concoction Poisonous Concoction to 7.

Be sure to check out our Flask Crafting Guide to learn everything you need to know about how to set up your non-Unique flasks.

Questions & Support

I made it a habit to check all comments in my guides on a daily basis. Obviously, there might be occurrences where getting a reply might take longer but I really do try to get back to you as soon as possible. I prefer you making remarks, suggestions or asking questions that way as it allows others to read through the comments, providing them with a potential answer to their question, without having to wait for me again. If I have somehow missed your question, you can try reaching me on our Discord.

If you enjoy my content to such an extent that you’d like to support me and my work, I have a Patreon you can check out. At no point should you feel pressured to contribute, but if you do, your support means more to me than you will ever imagine.

Short Guide Disclaimer

Due to the sudden rise in popularity and the necessity we feel to cover the guide on our platform, we opted to write this guide out in a short version. Feel free to come around on Discord and ask our thriving community for feedback or extra help if this guide didn’t cover all the information you sought.

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  1. Posts
    1

    Thank you for the build!

    I’d like to ask why is there a Multiple Traps support for the Utility 3 links under League Start. I haven’t played since 3.13 and plan to use this build as my starter for 3.17

  2. TbXie

    Moderator

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    1641

    Has to be multiple totems * Editing it! Good catch -sorry

  3. Posts
    1

    for the main links void manipulation support is put twice (unless i’m unaware that it stacks?)

  4. Posts
    4

    in your main links on the first page, you have Awakened Void Manipulation listed twice. Should one of those be vicious projectiles?

  5. Posts
    4

    On 04/02/2022 at 5:25 PM, rebotco said

    for the main links void manipulation support is put twice (unless i’m unaware that it stacks?)

    I think that’s a typo. I’d consider vicious projectiles in its place.

  6. TbXie

    Moderator

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    1641

    On 04/02/2022 at 5:39 PM, Ackedar said

    On 04/02/2022 at 5:25 PM, rebotco

    for the main links void manipulation support is put twice (unless i’m unaware that it stacks?)

    I think that’s a typo. I’d consider vicious projectiles in its place.

    Correct

  7. Posts
    1

    hello!

    sorry is the path of building link for this build accurate? when i click it all i get is jumbled text in the pastebin window ?

  8. Posts
    7

    On 05/02/2022 at 3:51 PM, mc2104dave said

    sorry is the path of building link for this build accurate? when i click it all i get is jumbled text in the pastebin window ?

    Hey buddy, PoB link works fine for me. You need to paste this into Path of Building. This is an external tool, free to download from github. Make sure to select the community fork edition, it is more advanced and offering way more in depth and accurate calculations.

  9. Posts
    9

    I’m probably too blind to see it but how does Ghost Dance work on this build with its super-low ES? In PoB it’s 120 ES, Ghost Dance has a potential to restore more than 600+.
    It is really worth taking the talent point for 120 ES restored every 2 secs?

    Question 2: Ancestral Protector now triggers Withered?! I thought only spell totem support does that?

    Thanks in advance.

  10. Posts
    51

    Any idea why there are multiple red circled passives on the passive tree in the PoB?

  11. Posts
    9

    OK I give up, my comments become inactive/hidden after a minute or so. Bye.

  12. TbXie

    Moderator

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    1641

    Ghost dance is worth, even for 120 es. Sure, if you can grab a tad more, its nice, but I wouldn’t say its required. 120 ES every 2 seconds for 1 point is incredibly good

    Heartgrave was answered on Discord afaik. I will do my best to make sure I leave no highlighted nodes when I upload a pob

  13. Posts
    1

    Thanks for the build. Is there a way in the PoB to see the best order to level up the build?

  14. TbXie

    Moderator

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    1641

    I generally don’t do leveling trees but PC is SO busted while leveling that it doesn’t matter

  15. Posts
    9

    What do you think of Cruelty support gem? (btw thanks for unlocking comments)

    When I put it in PoB it says +38% total DPS, that’s way more than either Void Man. or Vicious Proj. (both unawakened) give. I can see no downside to exchanging them with Cruelty unless maybe the red socket.
    Or do I miss something?

    PS: Keeping in mind PoB, even leaguestart, has awakened gems… they are equal or better to Cruelty, true. But no easy way to get them quickly, especially on SSF. So I guess Cruelty is a really good replacement for regular VM or VP.

  16. Posts
    1

    On 07/02/2022 at 2:15 PM, eronaile said

    What do you think of Cruelty support gem? (btw thanks for unlocking comments)

    When I put it in PoB it says +38% total DPS, that’s way more than either Void Man. or Vicious Proj. (both unawakened) give. I can see no downside to exchanging them with Cruelty unless maybe the red socket.
    Or do I miss something?

    PS: Keeping in mind PoB, even leaguestart, has awakened gems… they are equal or better to Cruelty, true. But no easy way to get them quickly, especially on SSF. So I guess Cruelty is a really good replacement for regular VM or VP.

    Cruelty can be good for DoT builds, but it’s generally better for bleed and ignite, since the magnitude of Cruelty’s effect is based on the damage of the hit, sort of like the new Fortification. So if each attack is doing a very small percentage of the enemy’s HP, you’ll only be getting about 15% more damage, rather than the full 40%.

  17. TbXie

    Moderator

    Posts
    1641

    Cruelty is definitely not what you want, especially not early game :-)

  18. Posts
    7

    On 06/02/2022 at 3:51 AM, Heartgrave said

    Any idea why there are multiple red circled passives on the passive tree in the PoB?

    I stumble upon this too. No worries. It is just because the Creator of that Tree had a Text typed in the Search field , on the bottom of the PoB tool. Remove that text from search and Nothing will be circled ;) It is just the search feature ob PathOfBuilding

  19. TbXie

    Moderator

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    1641

    Could be nice! You could try them out

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