Poisonous Concoction Pathfinder Build Guide (The Forbidden Sanctum 3.20)

TbXie

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Introduction

Poisonous Concoction Poisonous Concoction is a poison-based attack skill introduced in Path of Exile’s 3.16 Scourge League. It offers incredibly clear and an old overlapping style of scaling its damage to the point where it becomes an absolute powerhouse. For players who like to blast through the game on a budget and want a build that is minmaxable with an acceptable amount of currency and incredible returns, this is a one of a kind build.

Mechanics

This build relies on Pathfinder and the insane innate damage of Poisonous Concoction Poisonous Concoction to be able to scale defenses out of this world. In the endgame version it stacks Armour, Evasion, Suppression, Life and Elemental Damage reduction to achieve a very durable build. Whilst doing so, it maintains millions of Bossing DPS and way above acceptable clear speed.

The way the build works is by using Life Flask charges to scale up your damage. This is because of the flat added chaos damage you’re getting from the Poisonous Concoction gem. Other than that, there’s a couple of debuff mechanics such as curses (Despair Despair), damage increments (Wither Wither) and additional clear speed Plague Bearer Plague Bearer which round out the build to have it all.

The path of building offers you a starter set of gems & gear and a more optimized lategame selection of items.

Build Viability in Numbers

This is where I’ll rate the build in numbers. The lower the number the worse I actually think the build is in that compartment.

  • Durability : 9/10
  • Damage : 8/10
  • Playstyle : 9/10
  • Gearing : 9/10
  • Complexity : 7/10

Path of Building & Skill Tree

You can find an optimized Path of Building here. Every build I release will use the community fork of Path of Building, which is maintained and updated in a much more regular fashion than the original one. You can find PoB’s Fork, by LocalIdentity, here.

If you are not comfortable with Path of Building, we also have a PoePlanner for you. Do note that PoE Planner does not support Cluster Jewels and some specific unique jewels and it is highly recommended you install Path of Building to follow builds most optimally.

Gem Links

Endgame

Main Link: Poisonous Concoction Poisonous ConcoctionGreater Volley Support Greater Volley SupportAwakened Greater Multiple Projectiles Support Awakened Greater Multiple Projectiles SupportAwakened Unbound Ailments Support Awakened Unbound Ailments SupportAwakened Void Manipulation Support Awakened Void Manipulation SupportAwakened Vicious Projectiles Support Awakened Vicious Projectiles Support

Auras: Vaal Grace Vaal GraceMalevolence MalevolenceHerald of Agony Herald of AgonyDefiance Banner Defiance BannerDetermination DeterminationEnlighten Support Enlighten Support

Make sure to link them all to an enlighten level 3 (by splitting them up in different items).

Utility 1: Withering Step Withering Step Vaal Molten Shell Vaal Molten Shell Cast when Damage Taken Support Cast when Damage Taken Support Ancestral Protector Ancestral Protector

Utliity 2: Plague Bearer Plague BearerIncreased Area of Effect Support Increased Area of Effect SupportEnhance Support Enhance SupportBlood Rage Blood Rage

League Start

Main Link: Poisonous Concoction Poisonous ConcoctionGreater Volley Support Greater Volley SupportGreater Multiple Projectiles Support Greater Multiple Projectiles Support Unbound Ailments Support Unbound Ailments SupportVoid Manipulation Support Void Manipulation SupportVicious Projectiles Support Vicious Projectiles Support

Auras: Vaal Grace Vaal GraceMalevolence MalevolenceHerald of Agony Herald of AgonyDefiance Banner Defiance Banner

Utility 1: Withering Step Withering StepVaal Molten Shell Vaal Molten ShellCast when Damage Taken Support Cast when Damage Taken Support#

Utility 2: Plague Bearer Plague BearerIncreased Area of Effect Support Increased Area of Effect SupportBlood Rage Blood RageDespair Despair

Utility 3: Wither WitherAncestral Protector Ancestral ProtectorMultiple Totems Support Multiple Totems SupportFaster Casting Support Faster Casting Support

Gear Summary

Early Game – Leaguestart Environment:

Item Slot Item Name
Head Rare Evasion Helmet with Life, Resistance, Spell Suppression & a Poisonous Concoction AoE enchant
Amulet Agate Amulet Agate Amulet with Life & some Damage over Time Multiplier
Chest Rare Chestpiece with Life, Spell Suppression & Maximum Life as Energy Shield craft
Gloves Rare Evasion/Energy Shield with Life, chance to Suppress Spell Damage, Resistances (Potentially Attack Speed)
Boots Rare Evasion Boots with Life, Movement Speed, chance to Suppress Spell Damage & Resistances or Atziri's Step Atziri's Step
Belt Rare Belt with Strength, Life, Resistances
Rings Rare Rings with Life, Resistances & Attributes
Shield Lycosidae Lycosidae

Lategames:

Item Slot Item Name
Head Rare Evasion Helmet with Life, Resistance, Nearby Enemies take 9% increased Chaos Damage & a Poisonous Concoction AoE enchant
Amulet Catalysed Agate Amulet Agate Amulet with Life, Malevolence Reservation Efficiency, -8 Mana Cost, Area of Effect
Chest Rare Chestpiece with Life, Spell Suppression & Maximum Life as Energy Shield craft
Gloves Rare Evasion/Energy Shield with Life, Attack Speed, Chaos DoT Multi, Resistances
Boots Atziri's Step Atziri's Step
Belt Rare Belt with Strength, Life, % increased Life, Flask Effect, Resistances
Rings Catalysed Iolite Ring Iolite Rings with Life, Resistances, -8 Mana Cost, Despair on hit & Attributes
Shield Lycosidae Lycosidae
Jewels Increased Maximum Life, Chaos Damage over Time Multiplier, Damage with Poison

Flasks

1 Granite Flask Granite Flask of the Armadillo
2 Sulphur Flask Sulphur Flask of the Owl
3 Silver Flask Silver Flask of Dove
4 Saturated Eternal Life Flask Eternal Life Flask
5 Quicksilver Flask Quicksilver Flask of the Cheetah

The Cheetah affix should be swapped to a Catarina Benchcraft for Reduced Mana Costs once you swap to the late game aura setup to reduce the cost of your Poisonous Concoction Poisonous Concoction to 7.

Be sure to check out our Flask Crafting Guide to learn everything you need to know about how to set up your non-Unique flasks.

Questions & Support

I made it a habit to check all comments in my guides on a daily basis. Obviously, there might be occurrences where getting a reply might take longer but I really do try to get back to you as soon as possible. I prefer you making remarks, suggestions or asking questions that way as it allows others to read through the comments, providing them with a potential answer to their question, without having to wait for me again. If I have somehow missed your question, you can try reaching me on our Discord.

If you enjoy my content to such an extent that you’d like to support me and my work, I have a Patreon you can check out. At no point should you feel pressured to contribute, but if you do, your support means more to me than you will ever imagine.

Short Guide Disclaimer

Due to the sudden rise in popularity and the necessity we feel to cover the guide on our platform, we opted to write this guide out in a short version. Feel free to come around on Discord and ask our thriving community for feedback or extra help if this guide didn’t cover all the information you sought.

Changelog

  • Updated for 3.18 Sentinel

  • Build Created

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